The sunshine vitamin ( vitamin D3 ) plays a crucial role in women’s health. It is synthesized in skin under ultra - violet exposure. This biosynthesis will be inadequate in poor dietary intake or exposure to sunlight.
Deficiency occurs due to fat malabsorption, anticonvulsant use , Chronic Kidney disease , obesity , dark skinned people , people from areas with thicker ozone layer , women using sun-screen lotions & people from urban areas .
Rich sources of vitamin - D→ cod liver oil , salmon and sardines , fortified milk , egg , fortified yoghurt , fortified soy products , mushrooms , oysters , fortified cereals .
Exposure → Minimum - 400 IU ( 10 ng )
→ Maximum - 2,000 IU
→RAD for pregnant women - 200 IU/day .
Vitamin - D status indicator in body - serum concentration of 25 - hydroxyvitamin -D as it is major circulating form of vitamin in body .
Traditional role of calcium in body - calcium metabolism and bone mineral metabolism . It works with parathyroid hormones , acts on kidneys , bone , intestine and influence gene expression , maintains calcium and phosphorous homeostasis .
Emerging roles of vitamin - D→
→ Cell differentiation , proliferation and immune function .
→ Prevention/ treatment of some forms of cancer , osteoporosis , rheumatoid arthritis multiple sclerosis , hypertension , cardiovascular disease , obesity , psoriasis , and psychiatric diseases
Role of Vitamin - D in pregnancy →
With pregnancy there can be calcium loss due to foetal demands and increased urinary calcium excretion rate of vitamin - D deficiency are more with women with darker pigmentation and women who have limited access to sunlight or outdoor activity.
Type of clothing , cultural practices , thorough use of sunscreen.
Women including pregnant women with BMI > 30 are at increased risk of vitamin -D deficiency due to obesity .
Pregnant women with serum level of 25-OH vit.-D<75 nmol/2 are considered vit.-D deficient and should receive higher dose upto 1000 IU.
If this higher dose didnot work then they should be checked for celiac disease.
Infants bone to vitamin - D deficient mothers will be vitamin - D deficient & require supplementation in form of cholecalciferol bolus (50,000IU) to prevent rickets .
Role of Vitamin - D in other diseases →
→ Increased vitamin - D levels improve muscle performance and thus reduce muscle weakness .
→ Skin exposure to vr-rays has been linked with lower blood pressure.
→ Multiple sclerosis prevalent in temperate climates is associated with lower serum vitamin - D levels and vitamin - D supplementation may have a preventive role in multiple sclerosis .
→ The higher the vitamin - D level , lower the risk of cancer .
→ Vitamin - D act as immunosuppressant in rheumatoid arthritis .
→ Tuberculosis is associated with lower vitamin - D levels.
→ Social vulnerability of fairer sex is associated with lower vitamin - D levels .